miRegulome is an integrated online repository that provides entire regulatory modules of a miRNA, based on manually curated validated published data. Each module is hyperlinked to appropriate external database such as CTD, mir2Disease, miRNApath, KEGG, Entrez, and PubMed etc. to give the best possible picture of a miRNA regulome. The modules of a miRNA regulome consist of upstream regulators (transcription factors and various chemicals), downstream targets, pathways, functions, and disease associations etc. The relationships between modules and miRNA and experimental details have also been provided.
You can get the relationships among modules of a miRNA through searching the database by clicking the features under Database Statistics or using Search by Chemical. You can also search for a specific combination of modules (such as miRNA, species, function, disease etc.) using Advanced Search.
Novel reverse transcriptomics based analysis tools are also plugged in under Analysis feature for various types of user specific data analysis using the data available in miRegulome to get meaningful associations between Chemical-Disease, miR-Disease, Gene-Disease, and Disease-Chemical/miR.
miRegulome does not perform any enrichment analysis based on expression values. These tools mine the database and give relevant associations to the user by counting the associations (direct or indirect) between entries and rank them as per their count of associations (PubMed IDs). Additionally, the Z-scores work on these association counts to provide a fine grained ranking of the entities.